Coevolution at the proteome scale - Institute for Protein Design

Coevolution at the proteome scale - Institute for Protein Design

Today we report in Science the identification of hundreds of previously uncharacterized protein–protein interactions in E. coli and the pathogenic bacterium M. tuberculosis. These include both previously unknown protein complexes and previously uncharacterized components of known complexes. This research was led by postdoctoral fellow Qian Cong and included former Baker lab graduate student Sergey Ovchinnikov, now a John Harvard Distinguished Science

Big Data Shapes the Fold for of Hundreds of Protein Families - Institute for Protein Design

Learning Epistasis and Residue Coevolution Patterns: Current Trends and Future Perspectives for Advancing Enzyme Engineering

Improved protein structure prediction using predicted interresidue orientations

Co-evolutionary landscape at the interface and non-interface regions of protein-protein interaction complexes - ScienceDirect

Computed structures of core eukaryotic protein complexes

PDF) Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences

Deploying synthetic coevolution and machine learning to engineer protein- protein interactions

Predicting Proteome-Scale Protein Structure with Artificial Intelligence

Computed structures of core eukaryotic protein complexes

July, 2019 - Institute for Protein Design

Co-evolution of interacting proteins through non-contacting and non-specific mutations

News - Institute for Protein Design